SS-31 (Elamipretide)

SS-31, known scientifically as elamipretide (and historically as MTP-131 or Bendavia), is a synthetic, mitochondria-targeted tetrapeptide developed from the Szeto-Schiller peptide series. Its defining feature is an alternating aromatic-cationic structure that drives it selectively into the inner mitochondrial membrane, where it associates with the phospholipid cardiolipin. This positions SS-31 as one of the most studied tools in mitochondrial bioenergetics research. Bergdorf Bioscience supplies SS-31 (Elamipretide) at 10 mg per vial as a high-purity reference compound for laboratory and research use only.

Scientific Foundation and Study Background

Elamipretide emerged from work on aromatic-cationic peptides at Weill Cornell Medicine and has since accumulated an unusually deep clinical research record for a peptide, spanning Barth syndrome, primary mitochondrial myopathy, geographic atrophy in dry age-related macular degeneration, and heart failure. While several late-stage trials did not meet their primary endpoints, mechanistic and secondary findings have repeatedly pointed to genuine effects on mitochondrial structure and function.

• TAZPOWER (Barth syndrome): the randomized phase did not meet its primary endpoint, but the open-label extension showed improved knee-extensor muscle strength (and some cardiac measures) over extended follow-up, which supported elamipretide's 2025 FDA accelerated approval for Barth syndrome.
• MMPOWER-3 (primary mitochondrial myopathy): the primary six-minute-walk endpoint was not met, though reduced fatigue was reported in participants with specific mitochondrial DNA defects.
• ReCLAIM (dry AMD) and PROGRESS-HF (heart failure): primary endpoints were not achieved, but slowed ellipsoid-zone degradation and improved markers of mitochondrial function and quality of life were observed.

Biochemical Properties and Stability

SS-31 is a four-residue peptide built around the non-natural amino acid 2',6'-dimethyltyrosine (Dmt) and a D-arginine residue, which together give the molecule its characteristic aromatic-cationic motif and metabolic stability. The compound is highly water-soluble and is cleared rapidly, substantially by renal excretion, giving it a short systemic half-life. Lyophilized material should be stored cold and protected from light; reconstituted solutions are best kept refrigerated and used promptly.

• Sequence: H-D-Arg-Dmt-Lys-Phe-NH2 (D-Arg-2',6'-dimethyl-L-Tyr-L-Lys-L-Phe-amide)
• Molecular formula: C32H49N9O5
• Molar mass: about 639.8 g/mol
• CAS number: 736992-21-5 (free base); acetate salt 1334953-95-5
• PubChem CID: 11764719
• Systemic half-life: approximately 4 hours (roughly 2 to 4 hour range across species and route), with rapid, substantially renal clearance
• Molecular target: cardiolipin in the inner mitochondrial membrane (no classical cell-surface receptor)

Buy SS-31 (Elamipretide) at Bergdorf Bioscience

Each vial contains 10 mg of SS-31 (Elamipretide), manufactured to a verified purity of at least 99% and accompanied by third-party HPLC and mass-spectrometry documentation. Every batch is independently tested so that researchers receive material of consistent, reference-grade quality.

• >=99% purity confirmed by HPLC and mass spectrometry
• Certificate of Analysis (COA) available for every batch
• Supplied as a lyophilized powder, 10 mg per vial, for reconstitution in the laboratory
• Research protocol context only: elamipretide has been administered at about 40 mg subcutaneously once daily in clinical research; this is reference information, not dosing guidance (research context)
• Strictly for in vitro and laboratory research use; not for human or veterinary consumption

As a mitochondria-targeted compound, SS-31 is frequently studied alongside other cellular-energy and longevity research peptides such as MOTS-c and NAD+, making it a cornerstone of bioenergetics and aging research programs.

Worldwide Shipping

Bergdorf Bioscience ships SS-31 (Elamipretide) worldwide with discreet, temperature-conscious packaging and tracked delivery. Orders are processed promptly so that research-grade material reaches your laboratory in reliable condition.