Research peptide · Lys-Pro-Val
KPV
Buy KPV 10mg, the Lys-Pro-Val alpha-MSH fragment studied for NF-kB modulation. ✓>=99% purity ✓CoA included ✓cold-chain ✓fast EU shipping. Research use only.
Research peptide · Lys-Pro-Val
Buy KPV 10mg, the Lys-Pro-Val alpha-MSH fragment studied for NF-kB modulation. ✓>=99% purity ✓CoA included ✓cold-chain ✓fast EU shipping. Research use only.
Research peptide · Lys-Pro-Val
Buy KPV 10mg, the Lys-Pro-Val alpha-MSH fragment studied for NF-kB modulation. ✓>=99% purity ✓CoA included ✓cold-chain ✓fast EU shipping. Research use only.
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Order today → Delivery Tue, Oct 13 – Wed, Oct 21 to United States
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/ vial
Order today → Delivery Tue, Oct 13 – Wed, Oct 21 to United States
Payment Methods
Independently verified quality
3,000+
satisfied researchers
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
3,000+ satisfied researchers
KPV 10mg - 1 Pack vial + 2 ml BAC water → concentration:
Per unit (10 IU)
0.50 mg
Scientific references
Dalmasso et al. · Gastroenterology, 2008
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Kannengiesser et al. · Inflamm Bowel Dis, 2008
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Xiao et al. · Mol Ther, 2017
Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis
Research details
KPV is the linear tripeptide Lys-Pro-Val (single-letter K-P-V), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in research as an anti-inflammatory tripeptide whose hallmark is intracellular modulation of the NF-kB pathway. Bergdorf Bioscience supplies KPV as a 10mg lyophilized powder for laboratory research use only.
The dominant action of KPV is intracellular and largely receptor-independent. The tripeptide is taken up via the di/tripeptide transporter PepT1, then competitively blocks the interaction between the NF-kB subunit p65/RelA and importin-alpha3, preventing nuclear translocation of NF-kB. It also stabilizes IkB-alpha and inhibits MAPK signaling, which together down-regulate pro-inflammatory cytokine output.
KPV is a short linear melanocortin-derived fragment. Many research-grade preparations are supplied in the N-acetylated and amidated form (Ac-KPV-NH2), which differs slightly in mass from the free acid.
Each vial contains 10mg of lyophilized KPV. Choose the pack size that fits your research program:
Every batch is supplied at >=99% purity and ships with a Certificate of Analysis (CoA). Identity and purity are confirmed by HPLC and mass spectrometry, with full batch documentation for reproducible quality control.
KPV ships temperature-controlled from within the EU with discreet, tracked packaging. Store the lyophilized powder long-term at -20C; after reconstitution keep refrigerated at 2-8C and use within weeks. This product is sold strictly for laboratory research use and is not for human consumption.
Inhibits NF-κB nuclear translocation; reduces pro-inflammatory cytokine production; derived from α-MSH C-terminal signaling.
Advanced protocol
200-500 mcg subcutaneously or orally
Note: The dosages listed correspond to typical ranges from published research literature. They do not replace advice from a qualified researcher or physician.
Every batch is analyzed by an independent laboratory via HPLC before shipment. We document purity (avg. 99.43% in 2026), mass spectrometry identity, and sterility. Production follows GMP standards in ISO-certified laboratories.
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for its anti-inflammatory properties.
Independently verified quality
3,000+
satisfied researchers
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
3,000+ satisfied researchers
KPV 10mg - 1 Pack vial + 2 ml BAC water → concentration:
Per unit (10 IU)
0.50 mg
Scientific references
Dalmasso et al. · Gastroenterology, 2008
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Kannengiesser et al. · Inflamm Bowel Dis, 2008
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Xiao et al. · Mol Ther, 2017
Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis
Research details
KPV is the linear tripeptide Lys-Pro-Val (single-letter K-P-V), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in research as an anti-inflammatory tripeptide whose hallmark is intracellular modulation of the NF-kB pathway. Bergdorf Bioscience supplies KPV as a 10mg lyophilized powder for laboratory research use only.
The dominant action of KPV is intracellular and largely receptor-independent. The tripeptide is taken up via the di/tripeptide transporter PepT1, then competitively blocks the interaction between the NF-kB subunit p65/RelA and importin-alpha3, preventing nuclear translocation of NF-kB. It also stabilizes IkB-alpha and inhibits MAPK signaling, which together down-regulate pro-inflammatory cytokine output.
KPV is a short linear melanocortin-derived fragment. Many research-grade preparations are supplied in the N-acetylated and amidated form (Ac-KPV-NH2), which differs slightly in mass from the free acid.
Each vial contains 10mg of lyophilized KPV. Choose the pack size that fits your research program:
Every batch is supplied at >=99% purity and ships with a Certificate of Analysis (CoA). Identity and purity are confirmed by HPLC and mass spectrometry, with full batch documentation for reproducible quality control.
KPV ships temperature-controlled from within the EU with discreet, tracked packaging. Store the lyophilized powder long-term at -20C; after reconstitution keep refrigerated at 2-8C and use within weeks. This product is sold strictly for laboratory research use and is not for human consumption.
Inhibits NF-κB nuclear translocation; reduces pro-inflammatory cytokine production; derived from α-MSH C-terminal signaling.
Advanced protocol
200-500 mcg subcutaneously or orally
Note: The dosages listed correspond to typical ranges from published research literature. They do not replace advice from a qualified researcher or physician.
Every batch is analyzed by an independent laboratory via HPLC before shipment. We document purity (avg. 99.43% in 2026), mass spectrometry identity, and sterility. Production follows GMP standards in ISO-certified laboratories.
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for its anti-inflammatory properties.
KPV (Lys-Pro-Val): mechanism of action, dosages from studies, half-life, storage and distinctions. Read the research guide from the Bergdorf editorial team.
Peptide für Regeneration und Gewebeforschung: BPC-157, TB-500, KPV und Thymosin Alpha-1 in präklinischen Modellen eingeordnet.
KPV (Lys-Pro-Val): mechanism of action, dosages from studies, half-life, storage and distinctions. Read the research guide from the Bergdorf editorial team.
Peptide für Regeneration und Gewebeforschung: BPC-157, TB-500, KPV und Thymosin Alpha-1 in präklinischen Modellen eingeordnet.
