Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide and structural analog of the endogenous hormone alpha-melanocyte-stimulating hormone (α-MSH). The peptide was originally developed at the University of Arizona and belongs to the class of melanocortin peptides. The chemical sequence of Melanotan II is Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. Due to its cyclic structure, MT-2 exhibits significantly enhanced metabolic stability and an extended biological half-life of approximately 33 to 36 hours compared to linear α-MSH.

The mechanism of action of Melanotan 2 is based on binding to melanocortin receptors, a group of five G-protein-coupled receptors classified as MC1R through MC5R. While α-MSH preferentially binds to the MC1 receptor, MT-2 acts as a non-selective agonist with affinity for multiple subtypes of this receptor family. The MC1 receptor is predominantly expressed in cutaneous melanocytes and plays a central role in melanogenesis. The MC3R and MC4R receptors are primarily found in the central nervous system and are the subject of intensive research in the fields of energy homeostasis and neuroendocrine signaling pathways. MC5R is expressed in exocrine glands among other tissues and its physiological function has not yet been fully characterized.

The current state of research on Melanotan II encompasses numerous preclinical studies and a growing number of clinical investigations. The scientific literature accessible through PubMed examines various aspects of melanocortin signaling pathways, including the role of MC receptors in pigmentation, energy metabolism, and the regulation of autonomic functions. The cyclic heptapeptide structure of MT-2 makes the molecule a valuable tool in fundamental peptide chemistry research, particularly in the investigation of structure-activity relationships within the melanocortin peptide class. The improved resistance to enzymatic degradation compared to linear analogs enables reproducible experimental conditions in both in vitro and in vivo models.

The Melanotan 2 available from Bergdorf Bioscience is supplied as a lyophilized powder at a dosage of 10 mg per vial. Purity is a minimum of 99 percent, determined by high-performance liquid chromatography (HPLC). Each batch undergoes comprehensive quality control that includes HPLC purity analysis as well as mass spectrometric identity confirmation. Lyophilization ensures high long-term stability of the peptide when stored properly. We recommend storage at minus 20 degrees Celsius in a dry environment, protected from light.

This product is intended exclusively for research purposes and is not approved for human use. It must not be used as a pharmaceutical product or dietary supplement. Researchers requiring Melanotan 2 for scientific work in the fields of melanocortin receptor pharmacology, peptide chemistry, or related disciplines will find a research-grade product at Bergdorf Bioscience with complete documentation and reliable purity. MT-2 is particularly suited for studies on receptor selectivity, the investigation of cyclic peptide structures, and research into melanocortin signal transduction.

Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide and structural analog of the endogenous hormone alpha-melanocyte-stimulating hormone (α-MSH). The peptide was originally developed at the University of Arizona and belongs to the class of melanocortin peptides. The chemical sequence of Melanotan II is Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. Due to its cyclic structure, MT-2 exhibits significantly enhanced metabolic stability and an extended biological half-life of approximately 33 to 36 hours compared to linear α-MSH.

The mechanism of action of Melanotan 2 is based on binding to melanocortin receptors, a group of five G-protein-coupled receptors classified as MC1R through MC5R. While α-MSH preferentially binds to the MC1 receptor, MT-2 acts as a non-selective agonist with affinity for multiple subtypes of this receptor family. The MC1 receptor is predominantly expressed in cutaneous melanocytes and plays a central role in melanogenesis. The MC3R and MC4R receptors are primarily found in the central nervous system and are the subject of intensive research in the fields of energy homeostasis and neuroendocrine signaling pathways. MC5R is expressed in exocrine glands among other tissues and its physiological function has not yet been fully characterized.

The current state of research on Melanotan II encompasses numerous preclinical studies and a growing number of clinical investigations. The scientific literature accessible through PubMed examines various aspects of melanocortin signaling pathways, including the role of MC receptors in pigmentation, energy metabolism, and the regulation of autonomic functions. The cyclic heptapeptide structure of MT-2 makes the molecule a valuable tool in fundamental peptide chemistry research, particularly in the investigation of structure-activity relationships within the melanocortin peptide class. The improved resistance to enzymatic degradation compared to linear analogs enables reproducible experimental conditions in both in vitro and in vivo models.

The Melanotan 2 available from Bergdorf Bioscience is supplied as a lyophilized powder at a dosage of 10 mg per vial. Purity is a minimum of 99 percent, determined by high-performance liquid chromatography (HPLC). Each batch undergoes comprehensive quality control that includes HPLC purity analysis as well as mass spectrometric identity confirmation. Lyophilization ensures high long-term stability of the peptide when stored properly. We recommend storage at minus 20 degrees Celsius in a dry environment, protected from light.

This product is intended exclusively for research purposes and is not approved for human use. It must not be used as a pharmaceutical product or dietary supplement. Researchers requiring Melanotan 2 for scientific work in the fields of melanocortin receptor pharmacology, peptide chemistry, or related disciplines will find a research-grade product at Bergdorf Bioscience with complete documentation and reliable purity. MT-2 is particularly suited for studies on receptor selectivity, the investigation of cyclic peptide structures, and research into melanocortin signal transduction.