Semax

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide and an analog of the adrenocorticotropic hormone fragment ACTH(4–10). It was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Unlike full-length ACTH, Semax does not carry any hormonal effects, making it uniquely suited for targeted neurological research. Extensive studies have demonstrated that Semax possesses potent neuroprotective, nootropic, and neurotrophic properties, primarily mediated through the upregulation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF). These characteristics make Semax one of the most intensively studied neuropeptides in modern neuroscience research.

Key Research Findings

• BDNF and NGF Upregulation: Semax significantly increases the expression of Brain-Derived Neurotrophic Factor and Nerve Growth Factor, two critical neurotrophins involved in neuronal survival, synaptic plasticity, and long-term memory formation.
• Neuroprotection: Research models demonstrate that Semax provides robust neuroprotective effects against ischemic damage, oxidative stress, and excitotoxicity, supporting neuronal viability under adverse conditions.
• Cognitive Enhancement: Studies indicate that Semax enhances attention, learning capacity, and memory consolidation, consistent with its nootropic classification. These effects are attributed to downstream BDNF-mediated signaling cascades.
• Neurotrophic Activity: Beyond acute neuroprotection, Semax promotes neuronal growth, differentiation, and repair processes. Its neurotrophic effects persist well beyond its short plasma half-life, driven by sustained BDNF/NGF signaling.

Biochemical Properties and Stability

At Bergdorf Bioscience, Semax is supplied as a high-purity, lyophilized (freeze-dried) powder. This process removes moisture from the peptide, ensuring maximum chemical stability and a long shelf life even at room temperature.

• Amino Acid Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
• Molecular Weight: 813.93 g/mol
• CAS Number: 80714-61-0
• Plasma Half-Life: Approximately 2–3 minutes; however, biological effects persist significantly longer due to downstream BDNF/NGF signaling cascades.

Buy Semax at Bergdorf Bioscience

When you buy Semax for your laboratory, you need absolute reliability. At Bergdorf Bioscience, Semax is supplied in 30 mg vials, in three pack sizes for flexible research protocols:

• 1-Pack: one 30 mg vial
• 2-Pack: two 30 mg vials
• 3-Pack: three 30 mg vials

The price per vial goes down with the larger packs; the current prices are shown on this page. Every vial is filled under strict laboratory conditions and individually sealed. All batches are analyzed using High-Performance Liquid Chromatography (HPLC) and feature a guaranteed purity of at least 99%. Our quality assurance also includes detailed mass spectrometry (MS) to confirm the exact molecular weight, as well as rigorous endotoxin testing to ensure the highest standards for research applications.

Worldwide Shipping – Safe and Reliable

We offer reliable worldwide shipping for all our research peptides. Thanks to professional lyophilization, the Semax powder is highly temperature-stable in its unmixed state. The molecular integrity and biological activity of the peptide are fully preserved at normal ambient temperatures during global transit. After reconstitution (mixing with bacteriostatic water), we recommend proper storage in a refrigerator to maintain optimal stability.