Selank

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a modified analog of the naturally occurring immunopeptide tuftsin (Thr-Lys-Pro-Arg), extended with a Pro-Gly-Pro C-terminal tripeptide that dramatically enhances its metabolic stability and bioavailability. Selank exhibits a unique triple pharmacological profile—anxiolytic, nootropic, and immunomodulatory—without producing sedation, tolerance, or physical dependence, distinguishing it fundamentally from classical benzodiazepines. It modulates GABAergic, serotonergic (5-HT), and dopaminergic neurotransmission, making it one of the most versatile research neuropeptides available.

Key Research Findings

• GABAergic Modulation: Selank allosterically enhances GABAₐ receptor activity, promoting anxiolytic effects without the sedation or cognitive impairment typically associated with direct GABA agonists.
• Serotonin & Dopamine Pathways: Research demonstrates that Selank influences serotonin (5-HT) metabolism and dopamine turnover in the mesolimbic system, contributing to mood stabilization and emotional resilience.
• Anxiolytic Activity: In multiple preclinical models (elevated plus maze, open field, Vogel conflict test), Selank produces significant anxiolytic responses comparable to benzodiazepines—without motor impairment or withdrawal effects.
• Cognitive Enhancement: Selank enhances memory consolidation and learning performance in spatial navigation tasks and fear conditioning paradigms, likely via BDNF upregulation and hippocampal long-term potentiation.
• Immunomodulation: As a tuftsin analog, Selank retains potent immunomodulatory properties. It influences the expression of interleukin-6 (IL-6) and interferons, modulating both innate and adaptive immune responses without immunosuppression.

Biochemical Properties and Stability

At Bergdorf Bioscience, Selank is supplied as a high-purity, lyophilized (freeze-dried) powder. This manufacturing process removes moisture from the peptide, ensuring maximum chemical stability and a long shelf life even at ambient temperatures.

• Amino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
• Molecular Weight: 751.90 g/mol
• CAS Number: 129954-34-3
• Plasma Half-Life: Several minutes; however, the Pro-Gly-Pro C-terminal extension significantly enhances metabolic stability compared to native tuftsin, and downstream signaling effects persist well beyond plasma clearance.

Buy Selank at Bergdorf Bioscience

When you buy Selank for your research laboratory, you need absolute reliability and consistent quality. Selank is available at Bergdorf Bioscience as 10 mg lyophilized vials in convenient multi-pack options:

• 1-Pack (1 × 10 mg vial)
• 2-Pack (2 × 10 mg vials)
• 3-Pack (3 × 10 mg vials)

Every vial is filled under strict laboratory conditions and individually sealed. All batches are analyzed by High-Performance Liquid Chromatography (HPLC) and carry a guaranteed purity of ≥99%. Our quality assurance also includes mass spectrometry (MS) for molecular weight confirmation and rigorous endotoxin testing to ensure research-grade safety.

Worldwide Shipping – Safe and Reliable

We offer reliable worldwide shipping for all our research peptides. Thanks to professional lyophilization, Selank powder is highly temperature-stable in its unmixed state. The molecular integrity and biological activity of the peptide are fully preserved at normal ambient temperatures throughout global transit. After reconstitution (dissolving in bacteriostatic water), we recommend proper storage in a refrigerator.