Ipamorelin

Ipamorelin is a synthetic pentapeptide and one of the most selective growth hormone secretagogues identified to date. First described by Raun and colleagues in 1998 as 'the first selective growth hormone secretagogue,' it is studied in laboratory settings as a selective agonist of the ghrelin / growth hormone secretagogue receptor (GHS-R1a). Bergdorf Bioscience supplies ipamorelin at >=99% purity strictly for in-vitro and laboratory research.

Scientific Foundation and Study Background

Ipamorelin was originally developed by Novo Nordisk under the code NNC 26-0161. In the foundational study (Raun et al., European Journal of Endocrinology, 1998) it released growth hormone in anaesthetised rats with potency and efficacy comparable to GHRP-6, yet without the off-target hormone release that characterises earlier secretagogues. Subsequent human pharmacokinetic work (Gobburu et al., 1999) characterised its dose-proportional disposition and short terminal half-life.

• Released GH in anaesthetised rats with potency and efficacy comparable to GHRP-6 (ED50 ~80 nmol/kg) while preserving the natural pulsatile GH pattern (Raun et al., 1998).
• Did not produce significant elevations in ACTH, cortisol or prolactin at GH-stimulating doses, distinguishing it from GHRP-6 and pralmorelin (Raun et al., 1998).
• Displayed dose-proportional pharmacokinetics with a terminal half-life of ~2 hours in healthy human volunteers (Gobburu et al., Pharmaceutical Research, 1999).

Biochemical Properties and Stability

Ipamorelin is a five-residue peptide amide built from D-amino acids and non-proteinogenic residues, which confer resistance to enzymatic degradation and contribute to its receptor selectivity. The lyophilised powder is stable at -20 C and is reconstituted with sterile or bacteriostatic water immediately before research use.

• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 (pentapeptide amide)
• Molecular formula: C38H49N9O5
• Molar mass: 711.86 g/mol (free base)
• CAS number: 170851-70-4
• Terminal half-life: ~2 hours (human; Gobburu et al., 1999)
• Receptor target: GHS-R1a (ghrelin receptor)

Buy Ipamorelin at Bergdorf Bioscience

Each vial contains 10 mg of ipamorelin, supplied as a lyophilised powder for laboratory use. Every batch is HPLC-verified to >=99% purity, mass-confirmed by MS, and ships with a certificate of analysis.

• 10 mg lyophilised ipamorelin per vial (research context)
• >=99% purity confirmed by HPLC; identity verified by mass spectrometry
• Certificate of analysis available for every batch
• For in-vitro and laboratory research only; not for human or veterinary use

Ipamorelin is frequently studied alongside GHRH analogues such as CJC-1295 in growth-hormone-axis research models, where the two mechanisms are reported to act in a complementary manner (research context).

Worldwide Shipping

Bergdorf Bioscience ships ipamorelin worldwide with tracked, temperature-conscious packaging. Orders are dispatched promptly to research institutions and laboratories, subject to applicable import and research-use regulations in the destination country.