Calculadora de Meia-Vida de Peptídeos

How the Peptide Half-Life Calculator works

Enter a peptide, dose, dosing interval, and number of doses. The calculator plots the concentration over time as a percentage of the first-dose peak, and reports three key pharmacokinetic metrics: half-life, steady state, and accumulation.

First-order elimination

Peptides follow first-order elimination — a fixed percentage clears per unit time. The half-life is constant regardless of dose. After 7 half-lives, less than 1 % of the dose remains.

Steady state

When dosing regularly, a peptide accumulates until the amount taken in per dosing interval matches the amount eliminated. This equilibrium is called steady state and is reached at about 4.3 half-lives, independent of dose.

Why this tool uses % instead of mg

Plasma concentrations in mg or ng per mL require a volume of distribution that is only partially published for research peptides. A percent-of-peak Y-axis keeps the analysis honest: the relative clearance and accumulation are mathematically rigorous, while absolute plasma levels are not implied.