How long does SS-31 stay in the body?

SS-31 has a half-life of ~4 h. After roughly 7 half-lives less than 1 % of the administered dose remains.

When does SS-31 reach steady state?

With regular dosing, steady state is reached after about 4.3 half-lives.

How long does SS-31 stay in the body?

SS-31 has a half-life of ~4 h. After roughly 7 half-lives less than 1 % of the administered dose remains.

When does SS-31 reach steady state?

With regular dosing, steady state is reached after about 4.3 half-lives.

Elamipretide

SS-31 Half-Life Calculator

Visualize how your peptide clears from the body — half-life, steady state, and accumulation for every injection schedule.

Half-Life

~4 h

Time for 50 % to be eliminated

Steady State

~17 h

≈ 4.3 half-lives

Accumulation

×1.02

Cmax at steady state ÷ Cmax first dose

Gone After

~1.2 days

after last dose

Dose

Dosing interval

Number of doses

Source: FDA FORZINITY Integrated Review, 2025, Table 103: healthy subjects after intravenous infusion, six participants per cohort, cohort mean half-lives 3.23 to 3.93 hours. About four hours is a rounded IV study reference, supported by the FDA-reviewed original data rather than the Szeto review. It is not a universal SS-31 formulation or route value.. Research tool. Uses a simplified first-order elimination model and normalizes concentration to % of peak. Not a medical or dosing recommendation. SS-31: ~4 h.

Calculate SS-31 reconstitution & dosing→Build a stack with SS-31→Read the full SS-31 research guide→Scientific profile of SS-31 in the lexicon→