KPV

KPV is the linear tripeptide Lys-Pro-Val (single-letter K-P-V), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in research as an anti-inflammatory tripeptide whose hallmark is intracellular modulation of the NF-kB pathway. Bergdorf Bioscience supplies KPV as a 10mg lyophilized powder for laboratory research use only.

Scientific Background and Mechanism

The dominant action of KPV is intracellular and largely receptor-independent. The tripeptide is taken up via the di/tripeptide transporter PepT1, then competitively blocks the interaction between the NF-kB subunit p65/RelA and importin-alpha3, preventing nuclear translocation of NF-kB. It also stabilizes IkB-alpha and inhibits MAPK signaling, which together down-regulate pro-inflammatory cytokine output.

• PepT1-mediated uptake: Km ~160 uM in intestinal epithelial cells and ~700 uM in Jurkat immune cells (Dalmasso 2008).
• In a mouse colitis model, 100 uM KPV in drinking water reduced DSS- and TNBS-induced inflammation and lowered myeloperoxidase activity by ~50% (Dalmasso 2008).
• Suppression of IL-6, IL-8, IL-12, IFN-gamma and IL-1beta in vitro without lowering anti-inflammatory IL-10 (Land 2012).
• Unlike full alpha-MSH, KPV does not activate the MC1R cAMP pigmentary response in melanocytes (Land 2012).
• The C-terminal alpha-MSH sequence shows direct antimicrobial activity against S. aureus and C. albicans (Cutuli 2000).

Biochemical Properties and Stability

KPV is a short linear melanocortin-derived fragment. Many research-grade preparations are supplied in the N-acetylated and amidated form (Ac-KPV-NH2), which differs slightly in mass from the free acid.

• Amino Acid Sequence: H-Lys-Pro-Val-OH (K-P-V); residues 11-13 of alpha-MSH.
• Molecular Weight: C16H30N4O4, ~342.44 g/mol (free acid).
• Biological Half-Life: No validated human systemic half-life exists in the peer-reviewed literature; as an unprotected tripeptide KPV is rapidly degraded by peptidases, and commonly cited ~30 minute figures are unverified estimates (Songok 2018).

Buy KPV at Bergdorf Bioscience

Each vial contains 10mg of lyophilized KPV. Choose the pack size that fits your research program:

• KPV 10mg - 1 Pack
• KPV 10mg - 2 Pack
• KPV 10mg - 3 Pack

Every batch is supplied at >=99% purity and ships with a Certificate of Analysis (CoA). Identity and purity are confirmed by HPLC and mass spectrometry, with full batch documentation for reproducible quality control.

Worldwide Shipping - Safe and Hassle-Free

KPV ships temperature-controlled from within the EU with discreet, tracked packaging. Store the lyophilized powder long-term at -20C; after reconstitution keep refrigerated at 2-8C and use within weeks. This product is sold strictly for laboratory research use and is not for human consumption.