Research peptide · Epitalon
Epithalon (Epitalon/AEDG) 10mg, pineal tetrapeptide. ✓ ≥99% HPLC purity ✓ Lab-tested ✓ CoA online ✓ Shipped from the EU. For research use only.
No reviews yet. Be the first to share your experience.
/ vial
Order today → Delivery Tue, Sep 01 – Mon, Sep 07 to United States
Independently verified quality
3,000+
satisfied researchers
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
Epitalon 10mg - 1 Pack vial + 2 ml BAC water → concentration:
Per unit (10 IU)
0.50 mg
Scientific references
Khavinson et al. · Bull Exp Biol Med, 2003
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Kossoy et al. · In Vivo, 2006
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
Vinogradova et al. · Bull Exp Biol Med, 2007
Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimens
Research details
Epithalon (also known as Epitalon or the AEDG peptide) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed as a synthetic analogue of a peptide fraction isolated from the pineal gland and has become one of the most frequently referenced compounds in telomere and longevity research. Bergdorf Bioscience supplies Epithalon at 10mg per vial as a reference material for in-vitro and preclinical laboratory studies.
Most of the published work on Epithalon originates from the St. Petersburg Institute of Bioregulation and Gerontology, where investigators reported that the peptide can reactivate the catalytic subunit of telomerase (hTERT) in telomerase-negative human cell lines. In cell-culture models this has been associated with telomere elongation and continued cell division beyond the Hayflick limit. Later studies explored its role in pineal melatonin biosynthesis and in the epigenetic regulation of gene expression.
Epithalon is a small, unmodified linear tetrapeptide. It contains no D-amino acids, cyclic constraints, or N-methylations, so in solution it is expected to be rapidly hydrolysed by plasma and tissue peptidases. No formal pharmacokinetic study has quantified its systemic half-life.
Bergdorf Bioscience offers Epithalon (code ET10) at 10mg per vial as a research-grade reference standard, either as a single vial or in multi-vial packs; with the larger packs the price per vial goes down, and the current prices are shown on the product page. Every batch is supplied for laboratory research use only, and its analytical documentation is published on the website so that researchers can verify identity and purity before they order.
Reconstitution and handling should follow standard laboratory practice for lyophilised peptides; all storage and dilution decisions remain the responsibility of the qualified researcher.
Bergdorf Bioscience ships Epithalon worldwide as an ordinary tracked parcel in discreet, unbranded packaging. The lyophilised powder is stable at ambient temperature in transit, so no cold chain is needed; once it reaches the laboratory it is kept refrigerated.
Synthetic pineal tetrapeptide (AEDG). In research it reactivates hTERT/telomerase to elongate telomeres, binds the TERT-promoter region and linker histones H1.3/H1.6, and upregulates AANAT-driven melatonin synthesis.
Advanced protocol
Published research protocols (in-vitro and animal models) administer Epithalon reconstituted in bacteriostatic or sterile water across short cyclic courses (research context). Provided strictly for in-vitro and preclinical laboratory research, not for human consumption; no human dosing guidance is given.
Note: The dosages listed correspond to typical ranges from published research literature. They do not replace advice from a qualified researcher or physician.
Every batch is analyzed by an independent laboratory via HPLC before shipment. We document purity (avg. 99.43% in 2026), mass spectrometry identity, and sterility. Production follows GMP standards in ISO-certified laboratories.
Epithalon (also called Epitalon or the AEDG peptide) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed as a synthetic analogue of a pineal-gland peptide fraction and is widely referenced in telomere and longevity research. It is supplied for laboratory research use only.
Epithalon is the linear tetrapeptide Ala-Glu-Asp-Gly (AEDG), containing no D-amino acids or protective modifications.
Its molecular formula is C14H22N4O9 with a molar mass of approximately 390.35 g/mol (CAS 307297-39-8, PubChem CID 219042).
Research has examined Epithalon as a telomerase (hTERT) activator, for telomere elongation in cultured cells, for pineal melatonin biosynthesis, and for epigenetic regulation via binding to the TERT promoter region and linker histones. Much of the published work originates from a single research group.
No formal pharmacokinetic study has measured Epithalon's systemic half-life. As an unmodified tetrapeptide it is expected to be cleared by peptidases within minutes, but this has not been quantified in the literature.
No. Epithalon is an investigational research compound with no marketing approval in major jurisdictions. It was added to the FDA's Section 503A Category 2 bulk-substances list in September 2023; in April 2026 the FDA announced its removal from Category 2 and referral to its Pharmacy Compounding Advisory Committee (review scheduled July 2026), so its compounding status remains unsettled. It is sold strictly for in-vitro and preclinical laboratory research and is not for human consumption.
