How long does SS-31 stay in the body?

SS-31 has a half-life of ~4 hours. After roughly 7 half-lives less than 1 % of the administered dose remains.

When does SS-31 reach steady state?

With regular dosing, steady state is reached after about 4.3 half-lives.

Elamipretide

SS-31 Half-Life Calculator

Visualize how your peptide clears from the body — half-life, steady state, and accumulation for every injection schedule.

Half-Life

~4 h

Time for 50 % to be eliminated

Steady State

~17 h

≈ 4.3 half-lives

Accumulation

×1.02

Cmax at steady state ÷ Cmax first dose

Gone After

~1.2 days

after last dose

Concentration over time
Hour	% of peak
0	100
9.8	18.3
19.6	3.3
28.583	45.9
38.383	8.4
48	101.6
57.167	20.7
66.967	3.8
75.95	51.2
85.75	9.4
95.55	1.7
104.533	23.2
114.333	4.2
123.317	57.2
133.117	10.5
142.917	1.9
151.9	25.8
161.7	4.7
170.683	63.8
180.483	11.7
190.283	2.1

Dose

Dosing interval

Number of doses

Source: Szeto et al., elamipretide PK. Research tool. Uses a simplified first-order elimination model and normalizes concentration to % of peak. Not a medical or dosing recommendation. SS-31: ~4 hours.

Calculate SS-31 reconstitution & dosing→Build a stack with SS-31→

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