Tesamorelin

Tesamorelin (research code TH9507, marketed as Egrifta) is a synthetic growth hormone-releasing hormone (GHRH) analog comprising all 44 amino acids of endogenous human GHRH, enhanced with a trans-3-hexenoic acid modification at the N-terminus for improved receptor binding affinity and metabolic stability. It holds the unique distinction of being the first and only FDA-approved GHRH analog (approved in 2010) for the targeted reduction of excess abdominal fat associated with HIV-related lipodystrophy. This landmark regulatory approval, based on rigorous Phase III clinical data, underscores its exceptional safety and efficacy profile and sets Tesamorelin apart from other peptides in the growth hormone secretagogue class.

Landmark Clinical Studies: The Scientific Foundation

The clinical efficacy of Tesamorelin has been comprehensively validated in multiple large-scale, randomized, double-blind, placebo-controlled trials. The pivotal studies by Falutz et al., published in the Journal of Clinical Endocrinology & Metabolism (JCEM), demonstrated remarkable outcomes over treatment periods of 26 to 52 weeks:

• Significant Visceral Fat Reduction: Participants treated with Tesamorelin showed an average reduction in visceral adipose tissue (VAT) of approximately 15–18%, while placebo groups showed no significant change, a finding that directly supported FDA approval.
• Improved Lipid Profile: Significant reductions in triglyceride levels and improvements in the trunk-to-limb fat ratio were observed, indicating favorable metabolic effects beyond simple fat reduction.
• Enhanced Body Composition: Tesamorelin treatment led to improvements in overall body composition without the adverse metabolic effects often associated with exogenous growth hormone administration, such as impaired glucose tolerance.
• Cognitive Benefits: Emerging research suggests that Tesamorelin-stimulated GH release may have neuroprotective properties, with studies indicating improvements in cognitive function and potential relevance for age-related cognitive decline.

Biochemical Properties and Stability

At Bergdorf Bioscience, Tesamorelin is supplied as a high-purity, lyophilized (freeze-dried) powder. This sophisticated manufacturing process extracts moisture from the peptide, ensuring maximum chemical stability and an exceptionally long shelf life, even at room temperature.

• Amino Acid Sequence: [Hex]-His-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂ (where Hex = trans-3-hexenoic acid)
• Molecular Weight: Approximately 5,135.9 Da
• Biological Half-Life: The plasma half-life of Tesamorelin is approximately 26–38 minutes. Despite this relatively short half-life, its physiological mechanism of stimulating pulsatile endogenous growth hormone release provides sustained biological effects comparable to the body’s natural GH secretion pattern.

Buy Tesamorelin at Bergdorf Bioscience: Quality for the Highest Demands

When you buy Tesamorelin for your laboratory, you need absolute reliability. To guarantee maximum flexibility for diverse research protocols and dose-finding studies, Tesamorelin is available at Bergdorf Bioscience in two precisely defined dosages:

• 10 mg
• 20 mg

Each vial is filled under the strictest laboratory conditions and individually sealed. All batches are analyzed using High-Performance Liquid Chromatography (HPLC) and feature a guaranteed purity of at least 99%. Our uncompromising quality assurance also includes detailed mass spectrometry to confirm the exact molecular weight, as well as rigorous endotoxin testing.

Worldwide Shipping – Safe and Hassle-Free

We offer reliable worldwide shipping for all our research peptides. Thanks to professional lyophilization, the Tesamorelin powder is highly temperature-stable in its unmixed state. The molecular integrity and high biological activity of the peptide are fully preserved at normal ambient temperatures throughout global transit. However, after reconstitution (mixing with bacteriostatic water), we highly recommend proper storage in a refrigerator.