Research peptide · Lys-Pro-Val
Buy KPV 10mg, the Lys-Pro-Val alpha-MSH fragment studied for NF-kB modulation. ✓>=99% purity ✓CoA included ✓cold-chain ✓fast EU shipping. Research use only.
Research peptide · Lys-Pro-Val
Buy KPV 10mg, the Lys-Pro-Val alpha-MSH fragment studied for NF-kB modulation. ✓>=99% purity ✓CoA included ✓cold-chain ✓fast EU shipping. Research use only.
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Order today → Delivery Wed, Sep 16 – Thu, Sep 24 to United States
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/ vial
Order today → Delivery Wed, Sep 16 – Thu, Sep 24 to United States
Payment Methods
Independently verified quality
3,000+
satisfied researchers
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
3,000+ satisfied researchers
KPV 10mg - 1 Pack vial + 2 ml BAC water → concentration:
Per unit (10 IU)
0.50 mg
Scientific references
Dalmasso et al. · Gastroenterology, 2008
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Kannengiesser et al. · Inflamm Bowel Dis, 2008
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Xiao et al. · Mol Ther, 2017
Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis
Research details
KPV is the linear tripeptide Lys-Pro-Val (single-letter K-P-V), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in research as an anti-inflammatory tripeptide whose hallmark is intracellular modulation of the NF-kB pathway. Bergdorf Bioscience supplies KPV as a 10mg lyophilized powder for laboratory research use only.
The dominant action of KPV is intracellular and largely receptor-independent. The tripeptide is taken up via the di/tripeptide transporter PepT1, then competitively blocks the interaction between the NF-kB subunit p65/RelA and importin-alpha3, preventing nuclear translocation of NF-kB. It also stabilizes IkB-alpha and inhibits MAPK signaling, which together down-regulate pro-inflammatory cytokine output.
KPV is a short linear melanocortin-derived fragment. Many research-grade preparations are supplied in the N-acetylated and amidated form (Ac-KPV-NH2), which differs slightly in mass from the free acid.
Each vial contains 10mg of lyophilized KPV. Choose the pack size that fits your research program:
Every batch is supplied at >=99% purity and ships with a Certificate of Analysis (CoA). Identity and purity are confirmed by HPLC and mass spectrometry, with full batch documentation for reproducible quality control.
KPV ships temperature-controlled from within the EU with discreet, tracked packaging. Store the lyophilized powder long-term at -20C; after reconstitution keep refrigerated at 2-8C and use within weeks. This product is sold strictly for laboratory research use and is not for human consumption.
Inhibits NF-κB nuclear translocation; reduces pro-inflammatory cytokine production; derived from α-MSH C-terminal signaling.
Advanced protocol
200-500 mcg subcutaneously or orally
Note: The dosages listed correspond to typical ranges from published research literature. They do not replace advice from a qualified researcher or physician.
Every batch is analyzed by an independent laboratory via HPLC before shipment. We document purity (avg. 99.43% in 2026), mass spectrometry identity, and sterility. Production follows GMP standards in ISO-certified laboratories.
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for its anti-inflammatory properties.
Each vial contains 10mg of lyophilized KPV with no additives.
Store the lyophilized powder long-term at -20C. After reconstitution, keep refrigerated at 2-8C and use within a few weeks.
>=99% purity, verified by HPLC analysis. The Certificate of Analysis is available on our website.
The price per vial drops with the larger pack sizes. Current prices for each pack size are listed on the product page.
Discreet, trackable parcel shipping from within the EU. Orders over €250 ship free.
Independently verified quality
3,000+
satisfied researchers
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
99.43%
Avg. purity 2026
4.8 ★
ProvenExpert
3,000+ satisfied researchers
KPV 10mg - 1 Pack vial + 2 ml BAC water → concentration:
Per unit (10 IU)
0.50 mg
Scientific references
Dalmasso et al. · Gastroenterology, 2008
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Kannengiesser et al. · Inflamm Bowel Dis, 2008
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Xiao et al. · Mol Ther, 2017
Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis
Research details
KPV is the linear tripeptide Lys-Pro-Val (single-letter K-P-V), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in research as an anti-inflammatory tripeptide whose hallmark is intracellular modulation of the NF-kB pathway. Bergdorf Bioscience supplies KPV as a 10mg lyophilized powder for laboratory research use only.
The dominant action of KPV is intracellular and largely receptor-independent. The tripeptide is taken up via the di/tripeptide transporter PepT1, then competitively blocks the interaction between the NF-kB subunit p65/RelA and importin-alpha3, preventing nuclear translocation of NF-kB. It also stabilizes IkB-alpha and inhibits MAPK signaling, which together down-regulate pro-inflammatory cytokine output.
KPV is a short linear melanocortin-derived fragment. Many research-grade preparations are supplied in the N-acetylated and amidated form (Ac-KPV-NH2), which differs slightly in mass from the free acid.
Each vial contains 10mg of lyophilized KPV. Choose the pack size that fits your research program:
Every batch is supplied at >=99% purity and ships with a Certificate of Analysis (CoA). Identity and purity are confirmed by HPLC and mass spectrometry, with full batch documentation for reproducible quality control.
KPV ships temperature-controlled from within the EU with discreet, tracked packaging. Store the lyophilized powder long-term at -20C; after reconstitution keep refrigerated at 2-8C and use within weeks. This product is sold strictly for laboratory research use and is not for human consumption.
Inhibits NF-κB nuclear translocation; reduces pro-inflammatory cytokine production; derived from α-MSH C-terminal signaling.
Advanced protocol
200-500 mcg subcutaneously or orally
Note: The dosages listed correspond to typical ranges from published research literature. They do not replace advice from a qualified researcher or physician.
Every batch is analyzed by an independent laboratory via HPLC before shipment. We document purity (avg. 99.43% in 2026), mass spectrometry identity, and sterility. Production follows GMP standards in ISO-certified laboratories.
KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for its anti-inflammatory properties.
Each vial contains 10mg of lyophilized KPV with no additives.
Store the lyophilized powder long-term at -20C. After reconstitution, keep refrigerated at 2-8C and use within a few weeks.
>=99% purity, verified by HPLC analysis. The Certificate of Analysis is available on our website.
The price per vial drops with the larger pack sizes. Current prices for each pack size are listed on the product page.
Discreet, trackable parcel shipping from within the EU. Orders over €250 ship free.
KPV (Lys-Pro-Val): mechanism of action, dosages from studies, half-life, storage and distinctions. Read the research guide from the Bergdorf editorial team.
Peptide für Regeneration und Gewebeforschung: BPC-157, TB-500, KPV und Thymosin Alpha-1 in präklinischen Modellen eingeordnet.
KPV (Lys-Pro-Val): mechanism of action, dosages from studies, half-life, storage and distinctions. Read the research guide from the Bergdorf editorial team.
Peptide für Regeneration und Gewebeforschung: BPC-157, TB-500, KPV und Thymosin Alpha-1 in präklinischen Modellen eingeordnet.
