Epithalon

Epithalon (also known as Epitalon or the AEDG peptide) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed as a synthetic analogue of a peptide fraction isolated from the pineal gland and has become one of the most frequently referenced compounds in telomere and longevity research. Bergdorf Bioscience supplies Epithalon at 10mg per vial as a reference material for in-vitro and preclinical laboratory studies.

Scientific Foundation and Telomerase Research

Most of the published work on Epithalon originates from the St. Petersburg Institute of Bioregulation and Gerontology, where investigators reported that the peptide can reactivate the catalytic subunit of telomerase (hTERT) in telomerase-negative human cell lines. In cell-culture models this has been associated with telomere elongation and continued cell division beyond the Hayflick limit. Later studies explored its role in pineal melatonin biosynthesis and in the epigenetic regulation of gene expression.

• In cultured human fetal fibroblasts, Epithalon-treated cells continued dividing past passage 44, whereas untreated controls arrested near passage 34, with telomere lengths reported comparable to early-passage cultures.
• Rodent and Drosophila models reported lifespan extension on the order of 12 to 16 percent, alongside reduced lipid peroxidation and antimutagenic effects.
• Molecular docking and binding studies indicate interactions with the TERT promoter region and with linker histones H1.3 and H1.6, supporting a proposed epigenetic mechanism.

Biochemical Properties and Stability

Epithalon is a small, unmodified linear tetrapeptide. It contains no D-amino acids, cyclic constraints, or N-methylations, so in solution it is expected to be rapidly hydrolysed by plasma and tissue peptidases. No formal pharmacokinetic study has quantified its systemic half-life.

• Amino-acid sequence: Ala-Glu-Asp-Gly (AEDG)
• Molecular formula: C14H22N4O9
• Molar mass: approximately 390.35 g/mol
• CAS number: 307297-39-8
• PubChem CID: 219042
• Systemic half-life: not formally measured; expected to be on the order of minutes for an unmodified tetrapeptide

Buy Epithalon at Bergdorf Bioscience

Bergdorf Bioscience offers Epithalon (code ET10) at 10mg per vial as a research-grade reference standard, either as a single vial or in multi-vial packs; with the larger packs the price per vial goes down, and the current prices are shown on the product page. Every batch is supplied for laboratory research use only, and its analytical documentation is published on the website so that researchers can verify identity and purity before they order.

• Presented at 10mg per vial as a lyophilised powder (research context)
• Purity verified at >=99% by HPLC
• Third-party laboratory tested; the Certificate of Analysis is available on the website
• Intended solely for in-vitro and preclinical research, not for human consumption

Reconstitution and handling should follow standard laboratory practice for lyophilised peptides; all storage and dilution decisions remain the responsibility of the qualified researcher.

Worldwide Shipping

Bergdorf Bioscience ships Epithalon worldwide as an ordinary tracked parcel in discreet, unbranded packaging. The lyophilised powder is stable at ambient temperature in transit, so no cold chain is needed; once it reaches the laboratory it is kept refrigerated.